British cyclist Pfeiffer Georgi abandoned the Tour de France Femmes after getting caught up in a late crash on stage five, which also caused leader Demi Vollering to slip down the standings.
Georgi went down in a mass pile-up with 6.3km to go and her team DSM-Firmenich PostNL later confirmed she will no longer take part in the Tour.
The 23-year-old competed for Team GB at the Paris 2024 Olympics, finishing fifth in the women’s road race.
She had been 45th in the general classification going into stage five.
Blanka Vas of Hungary won Thursday’s stage, beating Kasia Niewiadoma, Liane Lippert and Kristen Faulkner in a late sprint.
Poland’s Niewiadoma now tops the overall standings, with Dutch rider Vollering slipping to ninth overall and losing one minute 47 seconds after falling.
Vollering, a team-mate of stage winner Vas, looked to be in pain as she battled to finish the 152.5km flat ride from Bastogne to Amneville.
Niewiadoma leads American Faulkner by 19 seconds going into Friday’s stage six, a 159.2km ride between Remiremont and Morteau.
General classification after stage five
1. Katarzyna Niewiadoma (Pol/Canyon-SRAM) 11hrs 27mins 29secs
2. Kristen Faulkner (US/EF–Oatly–Cannondale) +19secs
3. Puck Pieterse (Ned/Fenix-Deceuninck) +22secs
4. Cedrine Kerbaol (Fra/Ceratizit-WNT) +47secs
5. Juliette Labous (Fra/DSM-Firmenich PostNL) +56secs
6. Thalita de Jong (Ned/Lotto Dstny) +1min 4secs
7. Shirin van Anrooij (Ned/Lidl–Trek) +1min 7secs
8. Pauliena Rooijakkers (Ned/Fenix-Deceuninck) +1min 8secs
9. Demi Vollering (Ned/SD Worx) +1min 19secs
10. Liane Lippert (Ger/Movistar) +1min 20secs
Selected others
37. Anna Henderson (GB/Team Visma) +5mins 24secs
57. Lizzie Deignan (GB/Lidl-Trek) +11mins 33secs
84. Lizzie Holden (GB/UAE Team ADQ) +19mins 28secs
101. Alice Towers (GB/Canyon-SRAM) +20mins 17secs
125. Becky Storrie (GB/DSM-Firmenich PostNL) +28mins 15secs